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KMID : 0191120170320010095
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Journal of Korean Medical Science
2017 Volume.32 No. 1 p.95 ~ p.101
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Is Vitamin D an Independent Risk Factor of Nonalcoholic Fatty Liver Disease?: a Cross-Sectional Study of the Healthy Population
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Park Dan-Bee
Kwon Hyuk-Tae
Oh Seung-Won
Joh Hee-Kyung
Hwang Seung-Sik
Park Jin-Ho
Yun Jae-Moon
Lee Hye-Jin
Chung Goh-Eun
Ze Sang-Joon
Park Jae-Hong
Bae Ye-Seul
Lee A-Rang
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Abstract
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The association between vitamin D levels and nonalcoholic fatty liver disease (NAFLD) has been recognized. However, few studies showed independent associations between vitamin D deficiency and NAFLD after a sex-related adjustment for metabolic factors. We aimed to study whether vitamin D deficiency is an independent risk factor of NAFLD even after controlling for metabolic syndrome and visceral fat in both sexes. In this cross-sectional study, 7,514 Korean adults (5,278 men, 2,236 women) participated in a health check-up program. They underwent blood tests, abdominal computed tomography (CT) of the visceral fat area, and ultrasonography for NAFLD screening. Multiple logistic regression analysis was used to investigate the association of vitamin D deficiency with NAFLD according to the sex differences. Vitamin D deficiency is associated with NAFLD. The adjusted odds ratio (aOR) for NAFLD increased sequentially with decreasing vitamin D level, even after adjusting for metabolic syndrome and visceral fat. The subjects in the vitamin D sufficiency group (20?30 ng/mL) had an aOR for NAFLD of 1.18 (95% CI, 1.00?1.39), whereas the deficiency group (< 20 ng/mL) had an aOR of 1.29 (95% CI, 1.10?1.52). However, we have detected a significant sex-related interaction when analyzing the results. A significant relationship between vitamin D deficiency and NAFLD was found in men (aOR, 1.33; 95% CI, 1.11?1.60) but not in women.
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KEYWORD
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Vitamin D, Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome X, Intra-Abdominal Fat, Sex
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